刘雅，博士，教授
邮箱：yaliu@ouc.edu.cn
电话：0532-82032215
承担课程：
本科生课程《生物安全理论与法规》
研究生课程《高级生物化学》
学习工作经历：
2004~2008，高德注册，学士，生物技术专业
2008~2013，高德注册，博士, 海洋生物学专业
2012~2013，国家纳米科学中心，联合培养博士
2014~2015，高德注册，讲师
2016~2022，高德注册，副教授
2022~2023，新加坡国立大学，访问学者
2023~至今 高德注册，教授
主要科研领域：
申请人致力于生物医用材料的开发与组装调控研究，以阐释“分子结构设计与可控组装机制”为核心目的，系统研究了化学结构、组装行为和生物功能的关系。以第一和通讯作者在国内外主流刊物Advanced Materials、Biomaterials、Journal of Controlled Release 上发表论文40余篇, 申请和授权发明专利10余项，主持并参与了国家自然科学基金、国家重点研发计划、山东省自然科学基金等科研项目，荣获山东省自然科学学术创新奖、山东省优秀博士学位论文、山东省优秀硕士论文指导教师等多项学术奖励。
代表性成果：（#共同第一；*通讯作者）
1. Pengsheng Fan#,Yinghua Guan#,Xiaoying Zhang,Jiaqi Wang,Yinsheng Xu,Benli Song,Suling Zhang,Hao Wang, Ya Liu*, Zeng-Ying Qiao*. Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy.Nanoscale Horiz 2023, 8(9), 1226-1234.
2. Ting Wang#, Zheng He#, Cong-Shan Yuan, Zhen-Wei Deng, Fang Li, Xi-Guang Chen, Ya Liu*. MMP-responsive transformation nanomaterials with IAP antagonist to boost immune checkpoint therapy. J. Control. Release 2022, 343, 765–776.
3. Cong-Shan Yuan#, Zhuang Teng#, Shuang Yang#, Zheng He, Ling-Yang Meng, Xi-Guang Chen, Ya Liu*. Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy. J Control Release 2022, 351, 255–271.
4. Ying-Hua Guan, Na Wang, Zhen-Wei Deng, Xi-Guang Chen, Ya Liu*. Exploiting autophagy-regulative nanomaterials for activation of dendritic cells enables reinforced cancer immunotherapy. Biomaterials 2022, 282, 121434.
5. Di Qin#, Andi Zhang#, Na Wang, Yingxia Yao, Xiguang Chen, Ya Liu*. Hydroxybutyl chitosan/oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds. Appl. Mater. Today 2022, 26, 101342.
6. Mengjie Sun#, Di Qin#, Pengsheng Fan, Xiguang Chen, Ya Liu*. Chitosan-centered nanosystems as sustained therapeutics for allergic rhinitis intervention: Inhibition of histamine-induced cascades. J. Control. Release 2021, 335, 422-436.
7. Mei-Ping Tian#, An-Di Zhang#, Ying-Xia Yao, Xi-Guang Chen, Ya Liu*. Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing. Carbohyd. Polym. 2021, 261, 117878.
8. Ting Wang, Fangqin Wang, Mengjie Sun, Meiping Tian, Yuzhi Mu, Xiguang Chen, Ya Liu*. Gastric environment-stable oral nanocarriers for in situ colorectal cancer therapy. Int. J. Biol. Macromol. 139 (2019) 1035-1045.
9. Ya Liu*, Xi-Guang Chen*, Pei-Pei Yang, Zeng-Ying Qiao, Hao Wang. Tumor Microenvironmental pH and Enzyme Dual Responsive Polymer-Liposomes for Synergistic Treatment of Cancer Immuno-Chemotherapy. Biomacromolecules 2019, 20, 882−892.
10. Ya Liu, Di Zhang, Zeng-Ying Qiao, Guo-Bin Qi, Xing-Jie Liang, Xi-Guang Chen*, Hao Wang*. A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy. Adv Mater. 2015, 27, 5034–5042
